Researchers at the Faculty of Medicine of the University of Porto (FMUP) concluded that dysregulation of the genital and urinary microbiota may be associated with the development of prostate cancer, the most commonly diagnosed cancer in men aged 50 years and older.
A study published in the scientific journal Cancers establishes a link between prostate cancer and microbiota dysregulation. [flora intestinal]showing “promising” biomarkers for the diagnosis and treatment of the disease, FMUP said this Monday, in a statement.
Using RNA sequencing technology, the researchers compared the composition and diversity of bacteria present in the urine, glans, and prostate of men with and without cancer.
The researchers cited in the statement note that “the community of bacteria found in the urine of patients is clearly different from that analyzed in the urine of men without the disease” and that, in addition to a greater diversity of species, some types of bacteria are present in much higher numbers in the urine of patients with prostate cancer. .
According to the authors, the results of the study “show that men with prostate cancer do indeed have microbiota dysregulation.”
“This deregulation may contribute to chronic prostate inflammation and be implicated in the development of this type of cancer,” they say.
The results of the study show “significantly higher levels” of bacteria such as Streptococcus, Prevotella, Peptoniphilus, Negativicoccus, Actinomyces, Propionimicrobium and Facklamia in the urine of cancer patients.
In the head of these patients, bacteria of the genus Stenotrophomonas are isolated, and in the prostate gland – bacteria Alishewanella, Paracoccus, Klebsiella and Rothia.
“These data may point to promising biomarkers for the early diagnosis of prostate cancer and help the scientific community and clinicians find new therapeutic options,” they add.
The study is part of the Sexual Health and Prostate Cancer: Psychobiological Determinants of Sexual Health in Men with Prostate Cancer project, authored by Mikael Goncalves, Teresa Pina-Vaz, Angela Rita Fernandez, Isabel Miranda, Carlos Martins Silva, Acasio Gonçalves Rodriguez. and Carmen Lisboa.
Author: Portuguese
Source: CM Jornal
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