Specialists from the Institute of Physics developed analytical tools based on magnetic resonance imaging, which will allow monitoring the quality of biocompatible compounds for the manufacture of bone prostheses that can stimulate the natural growth of living tissues and the restoration of damaged parts of the body. from the Kazan Federal University (KFU), the university’s press service reported on March 18.
Director of the KFU Institute of Physics Marat Gafurov stated that composite materials based on biodegradable (bioabsorbable) polymers and calcium phosphates are considered promising for regenerative medicine:
“The combination of the properties of polymers (plasticity, hydrophilicity, solubility, swelling) and calcium phosphates (hemostatic and antibacterial) allows us to create products with the necessary biological and mechanical characteristics using 3D and 4D printing methods”.
Furthermore, if porous compounds are synthesized, they can also be impregnated with drugs. Such materials will significantly reduce the recovery time of bone tissue and the time required for rehabilitation of patients after soft tissue and bone injury and surgery.
The physics of living systems, according to Marat Gafurov, was created by the KFU Institute of Physics as a direction actively developed in collaboration with various Russian and foreign scientific organizations.
“Employees of various departments, mainly the Department of Quantum Electronics and Radio Spectroscopy, the Department of Physics of Molecular Systems and the Department of Medical Physics, as well as the research laboratories of our institute within the framework of the Priority 2030 program (address “ “Digital Genomics of Materials”) and other programs are dedicated to the calculation, synthesis and study of new materials for medicine.”– said Gafurov.
The results of one of the studies, carried out jointly with Russian and foreign scientists, were presented in the article “Analytical tools based on magnetic resonance for the study of polyvinylpyrrolidone-hydroxyapatite compounds”, recently published in the journal Polymers.
In their study, the scientists demonstrated the effectiveness of magnetic resonance methods for the study of hydroxyapatite organo-mineral ceramics (composites based on polyvinylpyrrolidone polymer and calcium phosphate).
“We also installed“Gafurov clarified, ” that these methods can be used to control the quality of these composites and develop tools that allow monitoring sample processing, resorption and degradation processes.”.
Georgy Mamin, associate professor in the Department of Quantum Electronics and Radiospectroscopy, explained the promise of a composite material based on polyvinylpyrrolidone and hydroxyapatite for the manufacture of bone prostheses:
“Polyvinylpyrrolidone (PVP) is a biocompatible polymer. It is possible to make an implant from it, which the body itself will destroy and eliminate over time, that is, a second operation will not be necessary to remove the implant. But if an implant is made of that material to replace a bone fragment, it will collapse faster than new bone forms. Therefore, PVP is mixed with hydroxyapatite, one of the main components of mammalian bones. When the body destroys the implant, it immediately receives material to build new bone.”.
Scientists are already conducting experiments on 3D printing bone fragments from such materials, but problems arise. One of them is the need to control the presence of harmful impurities in the polymer composition. Another problem is the quality control of the bonding of PVP with hydroxyapatite particles.
“Hydroxyapatite particles are difficult to destroy. “Electron paramagnetic resonance makes it possible to determine whether a compound has formed or decayed, which is important for biomedical applications.”“Mamin added to his explanation.
In their paper, the researchers described the ability to use magnetic resonance methods to monitor the composition of the starting materials and the final composite product, as well as to identify defects in the polymer-ceramic composite.
Specialists from the Institute of Metallurgy and Materials Science that bear his name. AA Baikov RAS, National Polytechnic University of Bucharest, Academy of Romanian Scientists, Institute of the Structure of Matter (Italy) and First Moscow State Medical University. I.M. Sechenov.
Source: Rossa Primavera
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